For mesothelioma treatment, extrapleural pneumonectomy surgery involves involving complete removal of the lung containing the tumor along with both the pleural layer that lines the chest cavity and the pleural layer that covers the lung, most of the diaphragm on the affected side and a part of the nerve that controls the movement of the diaphragm.
Extrapleural Pneumonectomy for Debulking of the Mesothelioma Tumor
When doctors talk about cytoreduction in reference to a malignancy, they are referring to debulking a tumor, which cannot be completely removed. By making the tumor smaller, it enhances the effectiveness of chemotherapy and/or radiation treatments that will be given after the surgery. Extrapleural pneumonectomy is the type of mesothelioma surgery used for cytoreduction. Even though the surgery is extremely complex, survival is possible, but it is dependent on a number of factors.
In a study titled Clinical and pathological features of three-year survivors of malignant pleural mesothelioma following extrapleural pneumonectomy, published online February 8, 2011 in the European Journal of Cardiothoracic Surgery, researchers examined the International Mesothelioma Program Patient Data Registry at Brigham and Women’s Hospital to find all patients who underwent extrapleural pneumonectomy for malignant pleural mesothelioma between January 1, 1988 and May 31, 2007. They identified 636 patients, 117 survived at least 3 years following surgery, including 26 remaining alive and four lost to follow-up.
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