Biphasic mesothelioma is one of the three main histologic subtypes of malignant mesothelioma. Approximately 20 to 35 percent of all malignant mesothelioma cases are classified as biphasic mesothelioma, making the biphasic subtype the second most common histologic form of the disease.Characteristics of Biphasic Mesothelioma Biphasic mesothelioma is made up of cells from both of the two other histologic categories of malignant mesothelioma, which include:
Epithelial mesothelioma – Epithelial mesothelioma is commonly comprised of round, cuboidal or polygonal cells that have long and slender microvilli, which are small hair-like protrusions in the cell membrane.
Sarcomatoid mesothelioma – Sarcomatoid mesothelioma is typically made up of spindle cells arranged in a disorganized fashion.
In biphasic mesothelioma, epithelial cells and sarcomatoid cells can exist in close proximity or, more frequently, within distinctly separate areas of a tumor. Biphasic mesothelioma is more common in pleural mesothelioma than peritoneal mesothelioma.
How Biphasic Mesothelioma is DiagnosedWhile the World Health Organization recommends that biphasic mesothelioma only be diagnosed when a tumor contains at least 10 percent of epithelial cells and 10 percent of sarcomatoid cells, a general consensus on this criteria has not been established in the medical community.
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